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KMID : 0370920140310020148
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Yeungnam Univercity Journal of Medicine
2014 Volume.31 No. 2 p.148 ~ p.151
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Delayed presentation of aggravation of thyrotoxicosis after radioactive iodine therapy at Graves disease
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Lee Ji-Hyun
Na Hyun-Jin
Park Jin-Woo
Lee Cheol-Ho
Han Hyun-Jeong
Kim Tae-Ho
Kim Se-Hwa
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Abstract
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Radioactive iodine (RAI) therapy is widely used for the treatment of Graves disease. After RAI therapy, 44% become hypothyroid and up to 28% remain hyperthyroid. The development of thyrotoxicosis after RAI therapy is believed to be mediated by 2 different mechanisms: a transient increased release of thyroid hormone due to radiation thyroiditis and the rare development of Graves disease due to the formation of antibodies to the thyroid-associated antigens released from the damaged follicular cells. A 55-year-old woman was hospitalized with severe headache, weight loss, and palpitation. She received a dose of 7 mCi of RAI (I-131) about 6 weeks earlier. Thyroid function test showed 7.98 ng/dL free T4, >8 ng/mL T3, <0.08 μIU/L thyroid stimulating hormone, and high titer thyroid stimulating immunoglobulin (TSI) (85.8 IU/L). She
improved with propylthiouracil, propranolol, and steroid treatment. The TSI, however, was persistently elevated for 11 months.
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KEYWORD
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Thyrotoxicosis, Graves disease, Radioactive iodine therapy
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